What Is EDURANT^®?

EDURANT^® is a prescription HIV medicine that helps to treat HIV infection in patients. It contains the HIV drug rilpivirine. This is a type of HIV medicine called a non-nucleoside reverse transcriptase inhibitor, or NNRTI.

EDURANT^® is a prescription medicine that is used with:

• other antiretroviral medicines to treat Human Immunodeficiency Virus (HIV-1) in people 12 years of age and older and who weigh at least 77 lbs (35 kg) who:
  • have never taken HIV medicines before, and
  • have an amount of HIV-1 in their blood (this is called ‘viral load’) that is no more than 100,000 copies/mL
• oral VOCABRIA (cabotegravir) for short term treatment of HIV-1 infection in people 12 years of age or older and who weigh at least 77 lbs (35 kg) when their healthcare professional determines that they meet certain requirements.

HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

If you take EDURANT^® in combination with oral VOCABRIA (cabotegravir), you should also read the Patient Information that comes with oral VOCABRIA (cabotegravir).

It is not known if EDURANT^® is safe and effective in children less than 12 years of age or who weigh less than 77 lbs (35 kg).

How EDURANT^® Works

Based on in vitro data, EDURANT^® blocks an enzyme in the body called HIV reverse transcriptase. HIV needs this enzyme to make more virus. When this enzyme is blocked, less virus is made in your body. When used with other HIV medicines, EDURANT^® may help:

• Reduce the amount of HIV in your blood
• Increase the number of CD4+ cells in your blood that help fight infection

Reducing the amount of HIV (your viral load) and increasing the CD4+ (T) cells in your blood may help improve your immune system. This may reduce your risk of death or getting infections that can happen when your immune system is weak (opportunistic infections).

The above information is based on in vitro data and not supported by clinical trials in humans.

Please read Important Safety Information below, and talk to your healthcare professional to learn if EDURANT^® is right for you.

Do not stop taking EDURANT^® or any other medicines without first talking to your healthcare professional.